BROMOENOL LACTONE

Name	BROMOENOL LACTONE
Synonyms	BEL HELSS HALOENOL LACTONE BROMOENOL LACTONE HALOENOL LACTONE SUICIDE SUBSTRATE E-6-(BROMOETHYLENE)TETRAHYDRO-3-(1-NAPHTHYL)-2H-PYRAN-2-ONE (E)-6-(BROMOMETHYLENE)TETRAHYDRO-3-(1-NAPTHALENYL)-2H-PYRAN-2-ONE (E)-6-(BROMOMETHYLENE)TETRAHYDRO-3-(1-NAPHTHALENYL)-2H-PYRAN-2-ONE
CAS	88070-98-8

Molecular Formula	C16H13BrO2
Molar Mass	317.18
Melting Point	103-106℃
Solubility	DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble
Appearance	White solid.
Storage Condition	-20°C
In vitro study	In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca 2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca 2+ ionophore A23187, which passively transports Ca 2+ down a concentration gradient and also in permeabilised mast cells where Ca 2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca 2+ signalling, both the release from internal stores and sustained elevation due to Ca 2+ influx.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

Biological activity	Bromoenol lactone ((6E)-Bromoenol lactone) is an irreversible selective and effective calcium-dependent phospholipase A2 (iPLA2β) inhibitor, its IC50 value is about 7 μM, which can inhibit antigen-stimulated mast cell exocytosis without preventing the influx of Ca2 +.
target	PLA2 7 μM (IC 50 )
in vitro study	in RBL 2H3 and bone marrow-derived mastcells (BMMCs), Ca 2 entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca 2 ionophore A23187, which passively transports Ca 2 down a concentration gradient and also in permeabilised mastcells where Ca 2 entry is no longer relevant. Moreover, bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca 2 signalling, both the release from internal stores and sustained elevation due to Ca 2 influx.

Last Update：2024-04-09 21:04:16

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Product Name: BROMOENOL LACTONE Visit Supplier Webpage Request for quotation
CAS: 88070-98-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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BROMOENOL LACTONE

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